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Name:

Chemotherapy for Stage B/C colon cancer

Description:

These are data from one of the first successful trials of adjuvant chemotherapy for colon cancer. Levamisole is a low-toxicity compound previously used to treat worm infestations in animals; 5-FU is a moderately toxic (as these things go) chemotherapy agent. There are two records per person, one for recurrence and one for death

Variables:

id:	id
study:	1 for all patients
rx:	Treatment - Obs(ervation), Lev(amisole), Lev(amisole)+5-FU
sex:	1=male
age:	in years
obstruct:	obstruction of colon by tumour
perfor:	perforation of colon
adhere:	adherence to nearby organs
nodes:	number of lymph nodes with detectable cancer
time:	days until event or censoring
status:	censoring status
differ:	differentiation of tumour (1=well, 2=moderate, 3=poor)
extent:	Extent of local spread (1=submucosa, 2=muscle, 3=serosa, 4=contiguous structures)
surg:	time from surgery to registration (0=short, 1=long)
node4:	more than 4 positive lymph nodes
etype:	event type: 1=recurrence,2=death

Link To Google Sheets:

Rows:

1776

Columns:

Files:

Chemotherapy for Stage B/C colon cancer_542_23.csv

License Type:

Public Domain (CC0)

References/Notes/Attributions:

References

JA Laurie, CG Moertel, TR Fleming, HS Wieand, JE Leigh, J Rubin, GW McCormack, JB Gerstner, JE Krook and J Malliard. Surgical adjuvant therapy of large-bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil: The North Central Cancer Treatment Group and the Mayo Clinic. J Clinical Oncology, 7:1447-1456, 1989.

DY Lin. Cox regression analysis of multivariate failure time data: the marginal approach. Statistics in Medicine, 13:2233-2247, 1994.

CG Moertel, TR Fleming, JS MacDonald, DG Haller, JA Laurie, PJ Goodman, JS Ungerleider, WA Emerson, DC Tormey, JH Glick, MH Veeder and JA Maillard. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. New England J of Medicine, 332:352-358, 1990.

CG Moertel, TR Fleming, JS MacDonald, DG Haller, JA Laurie, CM Tangen, JS Ungerleider, WA Emerson, DC Tormey, JH Glick, MH Veeder and JA Maillard, Fluorouracil plus Levamisole as an effective adjuvant therapy after resection of stage II colon carcinoma: a final report. Annals of Internal Med, 122:321-326, 1991.

R Dataset Upload:

Use the following R code to directly access this dataset in R.

d <- read.csv("https://www.key2stats.com/Chemotherapy_for_Stage_B_C_colon_cancer_542_23.csv")